By Free Republic | Created at 2025-01-12 04:16:53 | Updated at 2025-01-12 07:52:21
3 hours ago
Age matters: Kidney disorder indicator gains precision (Easy math formula)
Medical Xpress / Osaka Metropolitan University / Hypertension Research ^ | Jan. 6, 2025 | Akihiro Tsuda et al
Posted on 01/11/2025 8:11:18 PM PST by ConservativeMind
Annual health checkups regularly include urine tests that serve several purposes, including checking for symptoms of kidney disease. The presence of albumin in the urine is one indicator, as is glomerular filtration rate (GFR). In diabetic nephropathy, albuminuria first appears, leading to excessive filtration and eventually a decrease in GFR.
In the elderly, however, excessive filtration cannot be detected due to age-related GFR decline. To accurately assess GFR, researchers have come up with a new calculation method.
The group led by Dr. Akihiro Tsuda, a lecturer, assessed 180 kidney transplant donor candidates to define a new formula for determining the threshold value for hyperfiltration based on age and GFR values.
Among other findings, the conventional method of correcting for body surface area in obese patients was determined to be inaccurate as excessive filtration cannot be detected. The researchers suggest calculating GFR without the correction but by taking into account the decline in the filtration rate due to aging.
"Since hyperfiltration is a precursor to diabetic nephropathy, we hope that using this new formula will more accurately diagnose the condition, leading to early detection and treatment," stated Dr. Tsuda.
(Excerpt) Read more at medicalxpress.com ...
TOPICS: Health/Medicine
KEYWORDS: aging; albuminuria; kidney; nephropathy
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The magic formula to see if your strangely high “good” GFR is actually “bad” hyperfiltration, for anyone’s age, is:
GFR = -0.883 x AGE + 167.398
If your eGFR value is at or above what the GFR value is with that formula, you have kidney hyperfiltration, which is a bad sign and you need to see a doctor or tell your doctor you have the new definition of hyperfiltration.
Do not use the newer eGFR weight & height correction for body size, as they found it does not work to properly identify any relevant hyperfiltration determination.
This has relevance for me. My eGFR value, done without body size correction, is 104. With body correction, it’s over 135. With the formula above, I am 16 below the new formula approach for where hyperfiltration is a problem. Instead, it just shows my kidneys are very healthy and not actually dysfunctional (might be the GlyNAC and other supplements and foods I have posted here).
They tested this with a lot of patients using the actual GFR test with inulin, instead of the estimated GFR from creatinine or Cystatin C, as these two are not safely accurate with hyperfiltration patients. When you have hyperfiltration, your kidney cells are going crazy flushing your blood, and the concern is that they die off or go into senescence, leaving you with damaged kidneys. However, an accurate GFR test uses inulin and is time based and your kidneys are accurately tested for this condition.
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2 posted on 01/11/2025 8:11:52 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
To: ConservativeMind
I actually freaked out over a year or two ago, because I was in the hyperfiltration category, due to being on keto and seeing higher blood glucose numbers and having my body size correction be so high (was 143 then).
I read studies and it showed I should have gone to a kidney doctor and had the insulin test, but I just believed all the studies were wrong.
With this new study, I realize I was right, just without the proof or understanding.
3 posted on 01/11/2025 8:15:12 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
To: ConservativeMind
That is, my eGFR with body size correction was 143.
4 posted on 01/11/2025 8:15:55 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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