Blueberry-derived compound shows promise in enhancing colonic mucosal barrier function

By Free Republic | Created at 2024-09-26 05:06:19 | Updated at 2024-10-01 04:19:21 4 days ago

Blueberry-derived compound shows promise in enhancing colonic mucosal barrier function
Medical Xpress / Maximum Academic Press / Food Innovation and Advances ^ | Sept. 25, 2024 | Chunxue Zhang et al

Posted on 09/25/2024 9:51:13 PM PDT by ConservativeMind

A research team led by Dr. Bin Li has highlighted the potential of malvidin-3-O-galactoside (M3G), a blueberry-derived anthocyanin, to improve colonic mucosal barrier function and alleviate colitis symptoms. They demonstrated that M3G enhances the integrity of the colonic barrier by regulating key proteins and Notch signaling pathways, suggesting its potential as a natural therapeutic agent for intestinal diseases.

The colonic mucosal barrier is essential for maintaining digestive health, protecting against pathogens, and preventing inflammation. M3G, a common anthocyanin in blueberries, has been studied for its health benefits, including its potential to regulate gut microbiota and protect against inflammation.

The study used a mouse model of colitis induced by dextran sulfate sodium (DSS) to mimic the inflammatory bowel conditions.

Mice were treated with M3G, and the outcomes were compared with untreated controls. Mice treated with DSS exhibited significant weight loss and increased DAI scores compared to the control group, indicating severe colitis. However, M3G supplementation significantly increased body weight, reduced DAI scores, and improved food intake, suggesting a protective effect against colitis symptoms.

Histological analysis of colon tissues revealed extensive epithelial damage in DSS-treated mice. M3G supplementation significantly reduced these pathological changes, lowering HE scores, and enhancing mucosal thickness and goblet cell numbers, indicating improved physical barrier function. Molecular assessments showed that M3G enhanced the expression of key barrier proteins. Additionally, M3G improved immune barrier function by increasing levels of secretory immunoglobulin A (SIgA) and reducing elevated CD4+T and CD8+T cell percentages.

Further analysis demonstrated that M3G inhibited the over-activation of the Notch signaling pathway. These results collectively indicate that M3G can effectively alleviate colonic barrier dysfunction in colitis, highlighting its potential therapeutic application.

"Our findings suggest that M3G has a significant therapeutic potential to enhance colonic barrier function," said Dr. Xinyao Jiao.

(Excerpt) Read more at medicalxpress.com ...

TOPICS: Health/Medicine
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You can get malvidin-3-O-galactoside (M3G) by simply eating blueberries.

I am not aware of a supplement that assures this is caputured.

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2 posted on 09/25/2024 9:51:54 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)

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