Circadian rhythm disruption linked to lung inflammation

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Posted on 10/01/2024 8:19:22 PM PDT by ConservativeMind

In a study, researchers have explored the effects of circadian rhythm disruption on the lungs. They have found that nearly every cell in the body is keeping track of time.

The circadian rhythm helps synchronize the body's organ systems and regulate the immune system. If one of them goes off beat, the repercussions can affect the whole group.

Several factors influence circadian rhythm, including stress, physical activity and food intake; however, light and dark play the biggest role.

Circadian rhythm disruption occurs when the body's internal clock is out of sync with the environment. It can be caused by sleep habits, shift work or travel.

Previous research identified a link between circadian rhythm disruption and gut barrier function. Parthasarathy, a pulmonologist, wanted to know if a similar effect could be seen in the lungs.

For the study, researchers used lighting schedules to disturb the circadian rhythm of mice, essentially giving them jet lag. They also used lipopolysaccharides, which are part of the outer membrane of certain types of bacteria, to simulate acute lung injury.

When they evoked circadian rhythm disruption, the first thing they observed was an increase in acute lung inflammation due to an exacerbated immune response.

"There are more immune cells around when we are waking up and we are getting ready to go to sleep," Parthasarathy said, adding that the circadian rhythm cellular machinery also includes the parts of a cell that regulate inflammation. "This study shows just by having jet lag, your lungs might be more inflamed and more vulnerable to injury."

In addition to increased inflammation, this study marked the first time researchers were able to show increased lung permeability due to circadian disorganization and identify the gene dysregulation involved in the process.

(Excerpt) Read more at medicalxpress.com ...

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This seems to describe the need to reorient the body to a more normal time for sleeping and waking, otherwise, colon and lung permeability issues are more likely to occur, creating inflammation.

To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

2 posted on 10/01/2024 8:19:44 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)

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