By Free Republic | Created at 2024-12-21 16:39:35 | Updated at 2024-12-22 03:07:12
10 hours ago
Diabetes drug linked to increased risk of severe eye condition (GLP-1RAs / semaglutide)
Medical Xpress / University of Southern Denmark / medRxiv ^ | Dec. 16, 2024 | Nana Olejank Hansen / Emma Simonsen et al
Posted on 12/21/2024 8:30:09 AM PST by ConservativeMind
Two independent studies show that patients with type 2 diabetes who are treated with the drug Ozempic have an increased risk of developing damage to the optic nerve of the eye, which can lead to severe and permanent loss of vision.
Both of the new register-based studies from SDU confirm a concern that was raised earlier this year in a smaller American study.
"We have examined data from all 424,152 Danes with type 2 diabetes. We found that Ozempic more than doubles the risk of developing NAION. NAION is damage to the optic nerve of the eye caused by a sudden stop of blood flow to the optic nerve,," says Grauslund.
In Grauslund's study, the researchers divided the patients into two groups: those who were treated with Ozempic and those who received other treatment.
Anton Pottegård and his research group, who are experts on medicine use, have closely examined a smaller but more specific sample of the group of patients with type 2 diabetes. They have compared new users of Ozempic with users of another drug used in the treatment of diabetes who are at the same stage of the disease.
As with the American study, both studies show that Ozempic increases the risk of developing NAION and that this applies to everyone with type 2 diabetes and not just to those patients who are already very ill.
"The American study proposes a hypothesis about a possible association, so it was important to investigate," explains Pottegård.
"However, treatment with Ozempic should be stopped if NAION is detected in one eye. The vast majority of patients can be confident in receiving treatment with Ozempic, as the absolute risk is so low, but some people may prefer an alternative treatment following consultation with their doctor."
(Excerpt) Read more at medicalxpress.com ...
TOPICS: Health/Medicine
KEYWORDS: naion; ozempic; vision
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From the study abstract, Ozempic (also known as semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA)) had a hazard ratio of 2.81 versus sodium-glucose co-transporter 2 inhibitors (SGLT-2is) like Jardiance, Farxiga, or Brenzavvy.
The absolute risk was still quite low for Ozempic-type drugs, with an apparent increase of 1.41 people affected over 10,000 use years.
Do note there appears to be a likely reason for why Ozempic-type drugs are more inclined to do this, so keep this in mind when looking to use these weight loss drugs.
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2 posted on 12/21/2024 8:30:55 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
To: All
In before the “can I do it until I need glasses” jokes.
3 posted on 12/21/2024 8:31:59 AM PST by BipolarBob (As it was in the days of Noah they were feasting, drinking egg nog and celebrating Christmas.)
To: ConservativeMind
This happened to a close friend. She has lost about 40% of her vision.
4 posted on 12/21/2024 8:33:49 AM PST by ConjunctionJunction (Vim vi repellere licet)
To: ConservativeMind
New Wonder drug for weight loss, one eye at a time!
5 posted on 12/21/2024 8:38:19 AM PST by Delta 21 (If anyone is treasonous, it is those who call me such.)
To: ConjunctionJunction
“This happened to a close friend. She has lost about 40% of her vision.”
Was she on Ozempic, or something else?
6 posted on 12/21/2024 8:38:38 AM PST by BobL
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