By Free Republic | Created at 2024-10-18 03:52:59 | Updated at 2024-10-18 06:15:22
2 hours ago
High-density lipoproteins quality, not quantity, contribute to the first sign of Alzheimer's disease in women
Medical Xpress / University of Pittsburgh / The Journal of Clinical Endocrinology & Metabolism ^ | Oct. 11, 2024 | Meiyuzhen Qi et al
Posted on 10/17/2024 8:43:10 PM PDT by ConservativeMind
Higher levels of HDL-C—known as the "good cholesterol"—have been shown to correlate with heightened risk for Alzheimer's disease. A new study might explain why.
Once women reach the menopause transition, it's a matter of the quality, rather than quantity, of the total cholesterol carried by HDL particles circulating in a woman's bloodstream, and that quality declines over time, according to a research team.
HDL particles vary in their size, composition and level of functioning. The team measured these features in the blood of 503 women from the Study of Women's Health Across the Nation (SWAN) HDL ancillary study. The researchers found that, over time, the number of larger HDL particles in the women's bodies increased—and these larger particles, unfortunately, did not function as well as their smaller counterparts.
The researchers conducted repeated assessments of study participants' cognitive function from 2000 to 2016 and compared these data to changes in the women's HDL particles, composition and function as they aged.
"We were able to show that as early as midlife, women who have more of the smaller-sized particles and those whose particles' concentrations of phospholipids increased over the menopause transition are more likely to experience better episodic memory later in life," said Samar R. El Khoudary, Ph.D., M.P.H., adding that loss of working memory is the first sign of Alzheimer's disease.
Previously, El Khoudary's team has shown that health behaviors—such as those included in the American Heart Association's (AHA) Life's Essential 8—work to improve the quality of HDL particles..
"That's the good news in this developing picture of brain health and the 'not-so-good-after-all' cholesterol," said El Khoudary. "Even though higher levels of HDL-C may not be protective as you get older, there are things you can do that might help, even as early as your 40s."
(Excerpt) Read more at medicalxpress.com ...
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Large HDL particles are bad, while smaller ones are good for memory.
These can be tested, or you can do the AHA’s Life Essential 8 habits, which I’ll link in next.
To: ConservativeMind
2 posted on 10/17/2024 8:43:34 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...
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3 posted on 10/17/2024 8:44:05 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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