Tank Dell dislocated his knee, tore his ACL and suffered other damage against the Kansas City Chiefs last week.
Houston Texans head coach DeMeco Ryans revealed his wide receiver will undergo surgery and miss the rest of this season.
Dell was released from hospital after an overnight stay and was traveling back to Houston on Sunday.
He was injured on a 30-yard touchdown catch in Houston's 27-19 loss Saturday. He was coming across the back of the end zone and made the spectacular catch on a pass from C.J. Stroud before colliding with Houston teammate Jared Wayne on the way to the ground.
Dell immediately grabbed at his knee and Wayne signaled for team trainers, who spent several minutes working on the wide receiver while teammates waited anxiously.
Dell was eventually placed on a stretcher and driven in a covered medical cart off the field, and then he was taken to the hospital.
Tank Dell dislocated his knee, tore his ACL and suffered other damage against the Chiefs
Dell was released from hospital after an overnight stay and went back to Houston on Sunday
Dell's Texans teammate CJ Stroud appeared to be fighting back tears at seeing the injury
Ryans said that he has been in contact with Dell, but did not share any information about their conversations.
Dell had six catches for 98 yards and the touchdown when he was hurt with 11:40 left in the third quarter.
It's the second straight year Dell has sustained a season-ending injury. He fractured his fibula in Week 13 against the Broncos last season, just as the rookie was breaking out, and had surgery on it the following day.
Then in April, the 25-year-old was an innocent bystander at a private event in Sanford, Florida, when he sustained a minor gunshot wound.
Dell spent a brief amount of time in the hospital but was able to return to Houston soon afterward.
Dell, a third-round pick out of the University of Houston last year, ranks second on the team with 51 receptions for 667 yards and three touchdowns.
His injury is another blow to a team that was already missing Stefon Diggs after the four-time Pro Bowl receiver sustained a season-ending knee injury in Week 8.