By Free Republic | Created at 2025-01-12 03:51:58 | Updated at 2025-01-12 07:48:17
4 hours ago
How a simple amino acid could shape immune response (Asparagine helps antibodies)
Medical Xpress / University of Oxford / Science Immunology ^ | Jan. 3, 2025 | Yavuz F. Yazicioglu et al
Posted on 01/11/2025 7:28:28 PM PST by ConservativeMind
A study conducted by researchers has uncovered a pivotal role of asparagine metabolism in regulating B cell homeostasis and immune response.
Germinal center (GC) B cells are responsible for producing antibodies. The cells have some of the highest proliferation rates of all mammalian cells, yet their metabolism is unusual and incompletely understood, so a team from the Kennedy Institute and collaborators set out to understand more.
The findings identify the non-essential amino acid asparagine as a critical regulator of germinal center (GC) B cell function, structures critical for refining antibodies to target infections effectively.
"When asparagine is scarce, B cells struggle, leading to weakened GC B cell function," said Yavuz Yazicioglu, KTPS
Reducing asparagine levels through diet or an asparagine-depleting drug, Asparaginase, weakened GC B cell function, leading to lower-quality antibody generation during flu infection, particularly from the cells with a defective capacity to produce asparagine.
"We found when B cells were deprived of asparagine, they had reduced mitochondrial activity and building blocks such as nucleotides, suggesting asparagine sustains important metabolic processes in B cells," said Alex Clarke.
Clarke further commented on the significance of their findings, saying, "Our work highlights asparagine metabolism as a metabolic vulnerability in B cells that can be targeted to tackle diseases such as autoimmunity or malignancies with abnormal B cell immune responses."
(Excerpt) Read more at medicalxpress.com ...
TOPICS: Health/Medicine
KEYWORDS: aminoacid; asparagine; immuneresponse; simpleaminoacid
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Asparagine is common in meat, dairy, and eggs.
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2 posted on 01/11/2025 7:29:05 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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