Second women's ODI, Rajkot
India 370-5 (50 overs): Rodrigues 102, Deol 89; Prendergast 2-75
Ireland 254-7 (50 overs): Coulter Reilly 80, Forbes 38; Sharma 3-37
India won by 116 runs
India eased to a 116-run win over Ireland on Sunday to seal an ODI series victory in Rajkot.
The hosts started the three-match series with a six-wicket win on Friday and they comfortably eased past Ireland two days later.
Jemimah Rodrigues hit 102 and Harleen Deol added 89 as India posted a commanding total of 370-5.
It proved too much for the Irish although Christina Coulter Reilly shone with a maiden international half-century as she made 80.
Ireland's build-up to the match was overshadowed by 18-year-old spinner Aimee Maguire being reported for a suspect bowling action in Friday's first ODI.
Maguire, who took three wickets in the game, will be tested at an International Cricket Council-accredited testing centre over the next fortnight.
Cricket Ireland said it was giving "full support" to Maguire, who was not selected for Sunday's match despite being permitted to continue bowling in international cricket until the test results are known.
Ireland struggled to contain the India batters with captain Smriti Mandhana (73) and Pratika Rawal (67) putting on 156 for the opening partnership.
Rodrigues and Deol then combined for a 183-run stand as India posted a daunting target for Ireland to chase.
The tourists lost skipper Gaby Lewis for 12 before her opening partner Sarah Forbes (38) and Coulter Reilly took Ireland to 87-1.
Forbes fell and although Coulter Reilly and Laura Delany (37) put on 83 for the fourth wicket, Ireland were well behind the required run-rate.
Ireland could only manage 254-7 from their 50 overs with Deepti Sharma taking 3-37 while Orla Prendergast was the best of the Irish bowlers with 2-75.
The sides will meet again at the Niranjan Shah Stadium on Wednesday for the final ODI.