Jose Mourinho names former Manchester United midfielders Sofyan Amrabat and Fred in his starting line-up. Former Premier League players Caglar Soyuncu, Dusan Tadic and Allan Saint-Maximin also start.
Fenerbahce: Livakovic, Muldur, Djiku, Soyuncu, Samuel, Amrabat, Fred, Szymanski, Tadic, En Nesyri, Saint-Maximin.
Substitutes: Egribayat, Cetin, Akaydin, Yuksek, Yandas, Dzeko, Kahveci, Tosun, Dursun, Rodrigo Becao, Akcicek, Tograk.
Erik ten Hag makes four changes to his side from their 2-1 home win against Brentford in the Premier League on Saturday. Joshua Zirkzee, Manuel Ugarte, Victor Lindelof and Noussair Mazraoui come in. Bruno Fernandes is suspended after his red card against Porto on matchday two.
Manchester Utd: Onana, Lindelof, de Ligt, Martinez, Mazraoui, Eriksen, Ugarte, Dalot, Garnacho, Rashford, Zirkzee.
Substitutes: Bayindir, Heaton, Hojlund, Diallo, Casemiro, Antony, Wheatley, Amass, Ogunneye.