Quarterback Lamar Jackson starred as Baltimore Ravens sealed a 30-23 victory against the Los Angeles Chargers in the latest edition of the 'Harbaugh Bowl'.
Jackson got the Ravens on the board when he ran in a touchdown, before throwing for a further two.
It is the third time siblings John and Jim Harbaugh, who coach the Ravens and the Chargers respectively, have met in the NFL, with the former undefeated.
"This is a big win. Proud for our guys," John Harbaugh said.
"I just told him [Jim] you are a great coach and you have a great team and I love you."
In the previous two meetings, John led the Ravens to victory over Jim's San Francisco 49ers in a 2011 regular-season game before delivering on the big stage in the 2013 Super Bowl.
"It's pretty cool I'm part of history," Jackson said of the winning.
"We finished off the game the correct way. We started off slow - we've got to fix that and I believe we'll be where we want to be."
Jackson, the 2023 NFL Most Valuable Player, threw for 177 yards, while running back Derrick Henry ran 140 yards to spearhead Baltimore's attack.
"We just got in sync, hit the ground running, made the plays, went with what we know," said Jackson.
"Henry gets one carry and went for what he knows. That man, he can't be stopped."
The Ravens have won eight of their 12 games this season and sit second in the AFC North, while the Chargers are second in the AFC West with seven wins and four defeats.