By Free Republic | Created at 2025-01-12 04:52:11 | Updated at 2025-01-16 08:04:46
4 days ago
Study finds chemotherapy antidote could improve recovery after chemotherapy-induced kidney toxicity (Add glucarpidase)
Medical Xpress / Mass General Brigham / Blood Journal ^ | Shruti Gupta et al
Posted on 01/11/2025 8:31:01 PM PST by ConservativeMind
An FDA-approved medication called glucarpidase could serve as an antidote to kidney toxicity in patients receiving the chemotherapy drug methotrexate (MTX), according to a new study.
Using data from 28 major U.S. cancer centers, the researchers examined the association between glucarpidase treatment—which rapidly clears MTX from the blood—and outcomes of patients with MTX-induced acute kidney injury (AKI). They found that patients who received glucarpidase had significantly higher chances of kidney recovery compared to those who did not get this treatment.
"Glucarpidase is unique because it's one of the very few potential antidotes available to counteract the high rates of toxicity caused by chemotherapy," said Shruti Gupta, MD. "Even though glucarpidase was approved by the FDA in 2012, our study is the first to provide a comprehensive assessment of its potential clinical benefits."
Due to its ability to penetrate the blood-brain barrier, MTX is one of the most common chemotherapeutic agents used worldwide for cancers involving the central nervous system. However, high doses of MTX (defined as doses ≥ 500 g/m2) often cause severe complications such as AKI, liver toxicity, and neutropenia (i.e., low white blood cell count).
Glucarpidase converts MTX in the blood into inactive metabolites within 15 minutes of its administration. Despite its potent biochemical effects, no study has examined whether these effects translate into clinical benefit. Due to this evidence gap, there is widespread variation in the use of glucarpidase.
The study addresses this knowledge gap.
The analysis revealed that glucarpidase treatment was associated with a 2.7-fold increase in the chances of kidney recovery compared with no glucarpidase. Patients who received glucarpidase also had faster kidney recovery and a lower risk of severe neutropenia or liver toxicity compared to those who did not receive it.
(Excerpt) Read more at medicalxpress.com ...
TOPICS: Health/Medicine
KEYWORDS: glucarpidase; kidney; kidneys
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This appears to be used in limited places for this purpose, already, for those with kidney complication happening.
It would now seem to also work as a preventative with the chemo, so it seems doctors could just include it before a problem happens.
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2 posted on 01/11/2025 8:31:33 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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