By Free Republic | Created at 2024-10-21 05:13:27 | Updated at 2024-10-21 07:46:04
2 hours ago
Study links PFAS exposure to kidney function decline via gut microbiome
Medical Xpress / Keck School of Medicine of USC / Science of The Total Environment ^ | Oct. 17, 2024 | Hailey E. Hampson et al
Posted on 10/20/2024 10:09:22 PM PDT by ConservativeMind
New research has revealed that the connection between per- and polyfluoroalkyl substances, or PFAS, and kidney damage may be tied to dysregulation of the gut microbiome, which is made up of bacteria and other microorganisms that live in the digestive tract.
They found that increased PFAS exposure was associated with worse kidney function four years later, and that changes in the gut microbiome and related metabolites explained up to 50% of that decrease in function.
The researchers analyzed data from 78 participants, ages 17 to 22, enrolled in the Southern California Children's Health Study, a large-scale longitudinal effort to understand the effects of pollution on health.
At baseline, the researchers collected blood and stool samples that allowed them to measure PFAS exposure. At a follow-up appointment four years later, the researchers collected a second round of data on kidney function.
They found that when PFAS exposure increased by one standard deviation, kidney function was 2.4% worse at the follow-up visit.
The analysis revealed two separate groups of bacteria and metabolites that helped explain the effect of PFAS exposure on kidney function. One group explained 38% of the change in kidney function, and one group explained 50% of the change. Both groups of bacteria and metabolites performed beneficial activities, such as lowering inflammation in the body, that were hindered when PFAS exposure went up.
"We saw that exposure to PFAS was potentially altering the composition of the microbiome, associated with lower levels of beneficial bacteria and lower anti-inflammatory metabolites," Hampson said.
The findings provide a roadmap for researchers seeking to better understand the link between PFAS and kidney health. Hampson and her colleagues observed reductions in anti-inflammatory metabolites, as well as the bacteria that produce them, and increases in inflammatory metabolites.
(Excerpt) Read more at medicalxpress.com ...
TOPICS: Health/Medicine
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The authors seem to think that PFAS molecules hurt the bacteria that then don’t work right to provide the kidneys what they need, but PFAS should be capable of directly hurting the kidneys, as well.
Regardless, it would seem helpful to consider probiotic supplementation (kefirs or supplements) and healthy foods that may not be in high abundance in late teens, who served as the sample. This likely means fiber and nutrient-dense foods were not eaten, meaning these gut bacteria colonies don’t have what they need to recover.
Additionally, consider purified water sources and reducing the use of older Teflon-type pans, as other options. Catalytic carbon, followed by activated carbon, can sequester PFAS, and other filter types like ion exchange and reverse osmosis can also help.
Some city water has been found to have PFAS. I will provide information with a link, next.
To: ConservativeMind
2 posted on 10/20/2024 10:10:23 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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3 posted on 10/20/2024 10:10:57 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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