By Free Republic | Created at 2024-09-23 03:02:28 | Updated at 2024-09-30 11:43:27
1 week ago
Study: Naldemedine prevents opioid-induced constipation in patients with cancer
Medical Xpress / University of Tsukuba / Journal of Clinical Oncology ^ | Sept. 19, 2024 | Jun Hamano et al
Posted on 09/22/2024 7:09:59 PM PDT by ConservativeMind
Opioids, potent pain relievers for patients with cancer, frequently cause constipation, which is a significant issue. Researchers revealed that administering naldemedine, which is a constipation medication, alongside opioids effectively prevents opioid-induced constipation, thereby improving the patient's quality of life.
Pain relief for patients with cancer is crucial, and opioids, such as morphine, play a vital role. However, constipation, which negatively affects the patient's quality of life, is a common side effect of opioid administration. This condition, also known as opioid-induced constipation, is prevalent and frequently does not resolve on its own, thereby necessitating effective interventions.
A recent study aimed to investigate the effects of naldemedine, a medication used to treat constipation, in preventing constipation when patients with cancer begin receiving opioids. Naldemedine is anticipated to prevent constipation by promoting regular bowel movements.
The study involved 99 patients with cancer, categorized into two groups: one receiving naldemedine and the other a placebo. After 14 days of treatment, 64.6% of the patients taking naldemedine showed no signs of constipation compared with 17.0% in the placebo group. Furthermore, the naldemedine group demonstrated improved quality of life and reduced nausea.
In conclusion, the study indicates that naldemedine, when administered in conjunction with opioids for pain relief in patients with cancer, contributes to a more comfortable life by preventing constipation.
(Excerpt) Read more at medicalxpress.com ...
TOPICS: Health/Medicine
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It appears the amount of opioids used for cancer pain is enough to benefit from using naldemedine (Simproic) to reduce opioid-induced constipation.
To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...
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2 posted on 09/22/2024 7:10:31 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
To: ConservativeMind
this would be a godsend... gonna show it to my Doc.
3 posted on 09/22/2024 7:19:10 PM PDT by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. #FJB)
To: ConservativeMind
4 posted on 09/22/2024 7:29:15 PM PDT by Victor (If an expert says it can't be done, get another expert." -David Ben-Gurion, the first Prime Minister)
To: ConservativeMind
Major good news for those taking opiates for cancer or other intractable pain.
5 posted on 09/22/2024 7:31:16 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
To: ConservativeMind
A Fried bologna sandwich at a greasy spoon restaurant will do the same for $4.95
6 posted on 09/22/2024 7:39:22 PM PDT by Ikeon (If the we outlaw margarine, the world would be a butter place)
To: ConservativeMind
My mother had the worst problem with constipation while on opioids — to the extent that once her doctor had to make a house call to fix things.
They were quite hesitant to use laxatives on her since they were “habit forming”. When you’re 90+ years old, that’s the last thing you have to worry about.
To: Ikeon
wouldn’t a taco bell burrito work as good?
8 posted on 09/22/2024 7:45:23 PM PDT by Bob434
Drugs to fix other drugs.
9 posted on 09/22/2024 7:48:34 PM PDT by cherry
To: Chode
Yes. it truly would be a Godsend.
10 posted on 09/22/2024 7:52:09 PM PDT by ANKE69 ( ✌️ 🇺🇲 )
To: Ikeon
You know, I’ve had just that a while back, but I didn’t notice an issue.
I didn’t decide to get it again, though. It was okay, but not great.
11 posted on 09/22/2024 7:53:31 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
To: ANKE69
12 posted on 09/22/2024 7:54:57 PM PDT by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. #FJB)
To: ConservativeMind
Had a coworker who had cancer. After surgery she kept having pain so the doctor, rather then accept the idea that he had missed something, gave her major opioids for the pain.
Which ended up with her in the ER being roto-rutered.
It is something people joke about until they have seen it happen. It quickly becomes a lot less funny.
If this can help it will be a blessing.
13 posted on 09/22/2024 7:59:35 PM PDT by Harmless Teddy Bear ( Not my circus. Not my monkeys. But I can pick out the clowns at 100 yards.)
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