First full characterization of kidney microbiome unlocks potential to prevent kidney stones (Lactobacillus crispatus)

By Free Republic | Created at 2024-12-16 06:35:10 | Updated at 2024-12-16 08:43:05 2 hours ago

First full characterization of kidney microbiome unlocks potential to prevent kidney stones (Lactobacillus crispatus)
Medical Xpress / Cleveland Clinic / Nature Communications ^ | Dec. 11, 2024 | Agudelo, J. et al

Posted on 12/15/2024 10:17:40 PM PST by ConservativeMind

Researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal.

They also identified certain bacteria within the microbiome that could promote or block kidney stone development and showed that antibiotic misuse (commonly associated with kidney stone development in a hospital setting) skewed the microbiome towards stone-promoting bacteria.

The team's methods showed that bacteria living in the urinary tract were not only there because of disease, since they found them in the urinary tract of people without evidence of urologic disease.

Other studies had shown that two species Drs. Miller and Agudelo had identified—E. coli and Lactobacillus crispatus—had been associated with the presence and absence of kidney stones, respectively.

To see whether the kidney microbiome could influence stone formation, the researchers grew bacteria using a special chamber that mimics the movement of urine in our kidneys. They then added the "raw ingredients" of kidney stones, oxalate and calcium, to see what happened.

Several large, stone-like crystal structures formed in chambers growing E. coli. Chemical and X-ray analyses revealed these structures were indistinguishable from human kidney stones. No stones formed in the chambers growing Lactobacillus in this way.

Growing the two bacteria together resulted in very small crystal structures that were structurally and chemically different from kidney stones, indicating that Lactobacillus somehow blocks E. coli's ability to form kidney stones.

In preclinical models, the team also saw that antibiotic overuse shifted the balance of the kidney microbiome away from the healthy Lactobacillus towards the stone-forming E. coli.

Dr. Agudelo says his team's findings suggest that different bacteria produce pro- and anti- kidney stone molecules, which he wants to use in new therapeutic and diagnostic techniques.

(Excerpt) Read more at medicalxpress.com ...

TOPICS: Health/Medicine
KEYWORDS: biome; calcium; crispatus; ecoli; kidney; kidneymicrobiome; kidneys; kidneystones; lactobacillus; oxalate; stones; tract; urinary

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Lactobacillus crispatus, a probiotic available in formulations like Crispact, appears to block E. coli’s ability to make kidney stones. Antibiotics also appear to reduce Lactobacillus crispatus, which appears to help E. coli to later grow more unfettered.

Men, this probiotic is currently used by women to help with a healthy vaginal tract, but shouldn’t hurt men.

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2 posted on 12/15/2024 10:18:04 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)

To: ConservativeMind

3 posted on 12/15/2024 10:32:04 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)

To: ConservativeMind

Thank you. This is extremely interesting.

4 posted on 12/15/2024 10:34:51 PM PST by aposiopetic

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