By Free Republic | Created at 2024-11-19 00:27:26 | Updated at 2024-11-19 02:27:20
2 hours ago
Gut microbes play key role in regulating stress responsiveness throughout the day, research finds
Medical Xpress / University College Cork / Cell Metabolism ^ | Nov. 5, 2024 | Gabriel Tofani et al
Posted on 11/18/2024 4:21:50 PM PST by ConservativeMind
A pioneering study has uncovered the vital role that gut microbiota plays in regulating stress responses by interacting with the body's circadian rhythms.
The findings open the door for developing new microbial-based therapies that could help individuals better manage stress related mental health conditions, such as anxiety and depression which are often associated with alterations in circadian and sleep cycles.
This breakthrough research offers compelling evidence that the trillions of microorganisms in the gut orchestrate the body's hormonal responses to stress in a time-dependent manner, paving the way for new therapeutic approaches targeting the gut-brain axis.
This study shines a spotlight on the intricate relationship between the gut microbiota and the hypothalamic-pituitary-adrenal (HPA) axis, the body's central stress response system.
The research demonstrates that depletion of gut microbiota leads to a hyperactivation of the HPA-axis in a time-of-day specific manner, which, alongside alterations to the brain's stress and circadian responding regions, results in altered stress responsivity across the day.
The study further identifies specific gut bacteria, including a Lactobacillus strain (Limosilactobacillus reuteri), as key influencers of this circadian-regulated stress mechanism. L. reuteri emerged as a candidate strain that modulates glucocorticoid secretion (stress hormones), linking the microbiota's natural diurnal oscillations with altered stress responsiveness.
This discovery opens up new possibilities for psychobiotic interventions aimed at improving mental health outcomes by targeting gut bacteria that influence stress regulation.
With modern lifestyles increasingly disrupting circadian rhythms through irregular sleep patterns, high stress, and poor diet, this research underscores the importance of the gut microbiota in maintaining the body's natural stress-regulation processes.
Professor John Cryan said, "The gut microbiome doesn't just regulate digestion and metabolism; it plays a critical role in how we react to stress, and this regulation follows a precise circadian rhythm."
(Excerpt) Read more at medicalxpress.com ...
TOPICS: Health/Medicine
KEYWORDS: gut
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Reuteri is available by itself or with complexes, in supplement form, and in a a couple kefirs and yogurts.
They call this one out for helping with stress management.
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2 posted on 11/18/2024 4:22:23 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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