MotoGP will return to Brazil for the first time in more than two decades in 2026.
A five-year deal has been agreed for Goiania's Ayrton Senna circuit - named after the late Brazilian Formula 1 world champion - to host MotoGP until at least 2030.
Goiania, in central Brazil, hosted MotoGP from 1987-89 before the championship moved to Sao Paulo in 1992, with Rio de Janeiro most recently hosting from 1995 to 2004.
MotoGP said it has identified South America as a key market as it aims to expand its audience, with Argentina one of 22 destinations on the provisional 2025 calendar.
Carmelo Ezpeleta, CEO of MotoGP rights holder Dorna Sports, said: "This new agreement offers a fantastic opportunity to expand in a key market for the sport and our manufacturers.
"Brazil is a global player and somewhere we have always believed deserves a space on our calendar."
Spaniard Jorge Martin claimed his first MotoGP title in November.