Scientists Create First Hypoallergenic Gene-Edited Dogs

Scientists have used CRISPR gene-editing technology to create the first dogs lacking a key protein that triggers allergic reactions in humans, the Associated Press reported two months ago.

The study, published in *The CRISPR Journal*, describes how specialists from the US company Kindred Companion Sciences created two female Beagles—Bailey and Alfie. They “switched off” the gene responsible for producing the primary allergen found in dog saliva, fur, and dander.

To create the two dogs, scientists edited the gene responsible for producing the main allergenic protein in dogs. Bailey and Alfie were born in September 2024, and subsequent tests showed that this protein was absent from their saliva and fur.

The researchers also tested the effect on people with dog allergies. Geneticist Matt Walker, who suffers from such an allergy, showed no reaction when tested with samples from Bailey and Alfie, whereas he did react to other breeds, including Poodles and Goldendoodles.

According to the study’s authors, the dogs carry the edited gene, meaning the approach could potentially be applied to other breeds as well as to service dogs. However, further trials involving more people with dog allergies are needed to determine the technology’s effectiveness across a broader range of patients, the Associated Press noted.

Outside experts describe the results as promising but caution that it remains unclear whether eliminating just one of the allergenic proteins will be sufficient to prevent allergic reactions in everyone. They also point out that the potential commercialization of the technology raises ethical questions, including whether it might reduce interest in adopting these animals from shelters.

The project’s creators note that the gene editing performed on Bailey and Alfie mimics a rare but naturally occurring genetic variation found in some dogs. They plan to continue monitoring the health of both animals and to expand their research before the technology becomes available for widespread use, the Associated Press added.

Illustrative photo: pexels-daigofotos-32710697